Score |
Strand | Gene name |
Blattner ID |
Description |
EcoCyc link |
SwissProt comment |
| 2.928245 | - | fimZ | b0535 | fimbrial Z protein; probable signal transducer |
EG11103 |
SUBCELLULAR LOCATION: CYTOPLASMIC (PROBABLE).
SIMILARITY: TO OTHER BACTERIAL REGULATORY PROTEINS INVOLVED IN
SIGNAL TRANSDUCTION.
SIMILARITY: BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL
REGULATORS.
|
| 0.989214 | + | yjbN | b4049 | orf, hypothetical protein |
EG11932 |
SIMILARITY: BELONGS TO THE UPF0034 (NIFR3/SMM1) FAMILY. STRONG, TO
H.INFLUENZAE HI0634.
|
 | | yjbO | b4050 | orf, hypothetical protein |
EG11933 |
|
| 0.985437 | - | ybcI | b0527 | orf, hypothetical protein |
EG12708 |
|
| 0.874748 | + | hisL | b2018 | his operon leader peptide |
EG11269 |
FUNCTION: THIS PROTEIN IS INVOLVED IN THE ATTENUATION MECHANISM
FOR THE CONTROL OF THE EXPRESSION OF THE HIS STRUCTURAL GENES.
|
| | hisG | b2019 | ATP phosphoribosyltransferase |
EG10449 |
CATALYTIC ACTIVITY: 1-(5-PHOSPHO-D-RIBOSYL)-ATP + PYROPHOSPHATE =
ATP + 5-PHOSPHO-ALPHA-D-RIBOSE 1-DIPHOSPHATE.
PATHWAY: FIRST STEP IN HISTIDINE BIOSYNTHETIC PATHWAY. IS VERY
IMPORTANT IN THE REGULATION OF HISTIDINE METABOLISM.
SUBUNIT: HOMOHEXAMER.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO THE ATP PHOSPHORIBOSYLTRANSFERASE FAMILY.
|
| | hisD | b2020 | L-histidinal:NAD+ oxidoreductase; L-histidinol:NAD+ oxidoreductase |
EG10447 |
FUNCTION: THIS PROTEIN IS CONSIDERED AS A BIFUNCTIONAL ENZYME,
POSSESSING TWO ACTIVE SITES, ONE AN ALCOHOL DEHYDROGENASE AND
THE OTHER AN ALDEHYDE DEHYDROGENASE.
CATALYTIC ACTIVITY: L-HISTIDINOL + 2 NAD(+) = L-HISTIDINE +
2 NADH.
PATHWAY: TENTH STEP IN HISTIDINE BIOSYNTHETIC PATHWAY.
SUBUNIT: HOMODIMER.
SIMILARITY: TO OTHER PROKARYOTIC, FUNGAL AND PLANTS HDH.
|
| | hisC | b2021 | histidinol-phosphate aminotransferase |
EG10446 |
CATALYTIC ACTIVITY: L-HISTIDINOL-PHOSPHATE + 2-OXOGLUTARATE =
3-(IMIDAZOL-4-YL)-2-OXOPROPYL PHOSPHATE + GLUTAMATE.
COFACTOR: PYRIDOXAL PHOSPHATE.
PATHWAY: EIGHTH STEP IN HISTIDINE BIOSYNTHETIC PATHWAY.
SUBUNIT: HOMODIMER.
SIMILARITY: BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT
AMINOTRANSFERASES.
|
| | hisB | b2022 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase |
EG10445 |
CATALYTIC ACTIVITY: D-ERYTHRO-1-(IMIDAZOL-4-YL)GLYCEROL
3-PHOSPHATE = 3-(IMIDAZOL-4-YL)-2-OXOPROPYL PHOSPHATE + H(2)O.
CATALYTIC ACTIVITY: L-HISTIDINOL-PHOSPHATE + H(2)O = L-HISTIDINOL
+ ORTHOPHOSPHATE.
PATHWAY: SEVENTH & NINTH STEPS IN HISTIDINE BIOSYNTHETIC PATHWAY.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: IN THE C-TERMINAL SECTION; BELONGS TO THE
IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE FAMILY.
|
| | hisH | b2023 | glutamine amidotransferase subunit of heterodimer with HisF = imidazole glycerol phosphate synthase holoenzyme |
EG10450 |
FUNCTION: CATALYZES AN AMIDOTRANSFERASE REACTION THAT GENERATES
IMIDAZOLE-GLYCEROL PHOSPHATE AND 5-AMINOIMIDAZOL-4-CARBOXAMIDE
RIBONUCLEOTIDE, WHICH IS USED FOR PURINE SYNTHESIS.
PATHWAY: FIFTH STEP IN HISTIDINE BIOSYNTHETIC PATHWAY.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO THE HISH FAMILY.
SIMILARITY: CONTAINS 1 TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAIN.
|
| | hisA | b2024 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase |
EG10444 |
CATALYTIC ACTIVITY: N-(5'-PHOSPHO-D-RIBOSYLFORMIMINO)-5-AMINO-1-
(5''-PHOSPHORIBOSYL)-4-IMIDAZOLECARBOXAMIDE = N-(5'-PHOSPHO-D-1'-
RIBULOSYLFORMIMINO)-5-AMINO-1-(5''-PHOSPHORIBOSYL)-4-
IMIDAZOLECARBOXAMIDE.
PATHWAY: FOURTH STEP IN HISTIDINE BIOSYNTHETIC PATHWAY.
SUBUNIT: MONOMER.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO THE HISA / HISF FAMILY.
|
| | hisF | b2025 | imidazole glycerol phosphate synthase subunit in heterodimer with HisH = imidazole glycerol phsphate synthase holoenzyme |
EG10448 |
FUNCTION: CATALYZES THE CYCLIZATION REACTION THAT PRODUCES
D-ERYTHRO-IMIDAZOLE GLYCEROL PHOSPHATE.
PATHWAY: SIXTH STEP IN HISTIDINE BIOSYNTHETIC PATHWAY.
SUBUNIT: MONOMER.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO THE HISA / HISF FAMILY.
|
| | hisI | b2026 | phosphoribosyl-amp cyclohydrolase; phosphoribosyl-ATP pyrophosphatase |
EG10451 |
CATALYTIC ACTIVITY: 5-PHOSPHORIBOSYL-ATP + H(2)O =
5-PHOSPHORIBOSYL-AMP + PYROPHOSPHATE.
CATALYTIC ACTIVITY: 5-PHOSPHORIBOSYL-AMP + H(2)O =
5-(5-PHOSPHO-D-RIBOSYLAMINOFORMIMINO)-1-(5-PHOSPHO-RIBOSYL)
IMIDAZOLE-4-CARBOXAMIDE.
PATHWAY: SECOND AND THIRD STEPS IN HISTIDINE BIOSYNTHETIC PATHWAY.
SUBCELLULAR LOCATION: CYTOPLASMIC.
|
| 0.738567 | + | tsr | b4355 | methyl-accepting chemotaxis protein I, serine sensor receptor |
EG11034 |
FUNCTION: RECEPTOR FOR THE ATTRACTANT L-SERINE AND RELATED AMINO
ACIDS AND IS ALSO RESPONSIBLE FOR CHEMOTAXIS AWAY FROM A WIDE
RANGE OF REPELLENTS, INCLUDING LEUCINE, INDOLE, AND WEAK ACIDS.
FUNCTION: CHEMOTACTIC-SIGNAL TRANSDUCERS RESPOND TO CHANGES IN THE
CONCENTRATION OF ATTRACTANTS AND REPELLENTS IN THE ENVIRONMENT,
TRANSDUCE A SIGNAL FROM THE OUTSIDE TO THE INSIDE OF THE CELL, AND
FACILITATE SENSORY ADAPTATION THROUGH THE VARIATION OF THE LEVEL
OF METHYLATION. ATTRACTANTS INCREASE THE LEVEL OF METHYLATION
WHILE REPELLENTS DECREASE THE LEVEL OF METHYLATION, THE METHYL
GROUPS ARE ADDED BY THE METHYLTRANSFERASE CHER AND REMOVED BY THE
METHYLESTERASE CHEB.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE.
SIMILARITY: BELONGS TO THE CHEMOTAXIS SENSORY TRANSDUCERS FAMILY.
|
| 0.706063 | + | b1741 | b1741 | putative excinuclease subunit |
|
|
| 0.702040 | + | dbpA | b1343 | ATP-dependent RNA helicase |
EG10210 |
FUNCTION: COULD PLAY A MAJOR ROLE IN RIBOSOME ASSEMBLY,
SPECIFICALLY IN THE ASSEMBLY PROCESS OF THE ACTIVE CENTER OF 50S
RIBOSOMAL SUBUNITS. HAS AN ATP-DEPENDENT HELICASE ACTIVITY. CAN
UNWIND THE 23S RRNA AS WELL AS 16S RRNA. CAN HYDROLYSE ATP ONLY IN
THE PRESENCE OF BACTERIAL 23S RRNA.
SIMILARITY: BELONGS TO THE "DEAD" BOX FAMILY HELICASE.
|
| 0.584827 | + | b1729 | b1729 | part of a kinase |
EG13990 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (PROBABLE).
SIMILARITY: BELONGS TO THE SODIUM:DICARBOXYLATE SYMPORTER FAMILY
(SDF). STRONG, TO H.INFLUENZAE HI1154.
|
| 0.534804 | + | serS | b0893 | serine tRNA synthetase; also charges selenocystein tRNA with serine |
EG10947 |
CATALYTIC ACTIVITY: ATP + L-SERINE + TRNA(SER) = AMP +
PYROPHOSPHATE + L-SERYL-TRNA(SER).
SUBUNIT: HOMODIMER.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.
|
| 0.531471 | + | metF | b3941 | 5,10-methylenetetrahydrofolate reductase |
EG10585 |
CATALYTIC ACTIVITY: 5-METHYLTETRAHYDROFOLATE + ACCEPTOR =
5,10-METHYLENETETRAHYDROFOLATE + REDUCED ACCEPTOR.
COFACTOR: FAD.
PATHWAY: METHIONINE BIOSYNTHESIS.
SUBUNIT: HOMOTETRAMER.
SIMILARITY: BELONGS TO THE METHYLENETETRAHYDROFOLATE REDUCTASE
(EC 1.5.1.20/EC 1.7.99.5) FAMILY.
|
| 0.515222 | + | b2710 | b2710 | putative flavodoxin |
|
|
| | ygbD | b2711 | putative oxidoreductase |
EG12450 |
COFACTOR: FAD (BY SIMILARITY).
SIMILARITY: STRONG, TO FERREDOXINS/ADRENODOXINS REDUCTASES.
|
| 0.483741 | - | b3975 | b3975 | orf, hypothetical protein |
|
|
| 0.441093 | + | b1446 | b1446 | orf, hypothetical protein |
EG13768 |
|
| 0.412777 | + | b2389 | b2389 | orf, hypothetical protein |
|
|
| | b2390 | b2390 | orf, hypothetical protein |
EG14385 |
SIMILARITY: TO E.COLI YAAX.
|
| | b2391 | b2391 | orf, hypothetical protein |
|
|
| 0.389992 | + | hdeD | b3511 | orf, hypothetical protein |
EG11495 |
|
| 0.386763 | + | rcsA | b1951 | positive regulator for ctr capsule biosynthesis, positive transcription factor |
EG10820 |
FUNCTION: POSITIVE REGULATOR OF CAPSULAR POLYSACCHARIDE
SYNTHESIS. RCSA AND RCSB FORM A COMPLEX TO PROMOTE TRANSCRIPTION
OF THE GENES FOR CAPSULE SYNTHESIS.
MISCELLANEOUS: DEGRADATION OF THE RCSA PROTEIN IN VIVO DEPENDS ON
THE LON PROTEASE. ITS STABILITY IS INCREASED BY RCSB. RCSA* IS
MORE STABLE THAN RCSA.
SIMILARITY: BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL
REGULATORS.
|
| 0.379440 | + | ybbX | b0512 | putative hydrolase |
EG13619 |
FUNCTION: INVOLVED IN THE ANAEROBIC UTILIZATION OF ALLANTOIN.
CATALYTIC ACTIVITY: ALLANTOIN + H(2)O = ALLANTOATE.
COFACTOR: ZINC (BY SIMILARITY).
PATHWAY: FIRST STEP IN THE DEGRADATION OF ALLANTOIN (PURINE
CATABOLISM).
INDUCTION: BY GLYOXYLATE.
SIMILARITY: BELONGS TO THE DHOASE FAMILY.
|
| | ybbY | b0513 | putative transport |
EG13620 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (POTENTIAL).
INDUCTION: BY GLYOXYLATE.
SIMILARITY: BELONGS TO THE XANTHINE/URACIL PERMEASES FAMILY.
STRONG, TO B.SUBTILIS YWDJ.
|
| | ybbZ | b0514 | orf, hypothetical protein |
EG13621 |
CATALYTIC ACTIVITY: ATP + (R)-GLYCERATE = ADP + 3-PHOSPHO-(R)-
GLYCERATE.
PATHWAY: GLYOXYLATE CATABOLISM.
INDUCTION: BY GLYOXYLATE.
SIMILARITY: BELONGS TO THE UPF0068 FAMILY.
|
| 0.378000 | - | yefM | b2017 | orf, hypothetical protein |
EG12844 |
SIMILARITY: BELONGS TO THE PHD/YEFM FAMILY.
|
| 0.365285 | + | yafM | b0228 | orf, hypothetical protein |
EG13150 |
SIMILARITY: STRONG, TO H.INFLUENZAE HI0217.
|
| 0.352960 | + | pta | b2297 | phosphotransacetylase |
EG20173 |
CATALYTIC ACTIVITY: ACETYL-COA + ORTHOPHOSPHATE = COA +
ACETYL PHOSPHATE.
PATHWAY: LAST OF TWO STEPS IN THE CONVERSION OF ACETATE TO
ACETYL-COA.
SUBCELLULAR LOCATION: CYTOPLASMIC (POTENTIAL).
SIMILARITY: IN THE N-TERMINAL SECTION; CONTAINS A DOMAIN WITH SOME
SIMILARITIES WITH COBQ/BIOD.
SIMILARITY: IN THE C-TERMINAL SECTION; BELONGS TO THE PHOSPHATE
ACETYLTRANSFERASE AND BUTYRYLTRANSFERASE FAMILY.
|
| 0.347465 | + | tauA | b0365 | taurine transport system periplasmic protein |
EG13300 |
FUNCTION: PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM FOR
TAURINE.
SUBCELLULAR LOCATION: PERIPLASMIC (POTENTIAL).
SIMILARITY: TO SYNECHOCYSTIS PCC 6803 SLL0473.
|
| | tauB | b0366 | taurine ATP-binding component of a transport system |
EG13299 |
FUNCTION: PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM FOR
TAURINE. PROBABLY RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT
SYSTEM.
SUBCELLULAR LOCATION: INNER MEMBRANE-ASSOCIATED (POTENTIAL).
SIMILARITY: BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY
(ABC TRANSPORTERS).
|
| | tauC | b0367 | taurine transport system permease protein |
EG13301 |
FUNCTION: PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM FOR
TAURINE. PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF THE
SUBSTRATE ACROSS THE MEMBRANE.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(POTENTIAL).
SIMILARITY: WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-
PROTEIN-DEPENDENT TRANSPORT SYSTEMS. BELONGS TO THE CYSTW
SUBFAMILY.
|
| | tauD | b0368 | taurine dioxygenase, 2-oxoglutarate-dependent |
EG12423 |
FUNCTION: CONVERTS TAURINE AND ALPHA KETOGLUTARATE TO SULFITE,
AMINOACETALDEHYDE AND SUCCINATE. REQUIRED FOR THE UTILIZATION OF
TAURINE (2-AMINOETHANESULFONIC ACID) AS A SULFUR SOURCE. OPTIMAL
PH FOR ACTIVITY IS 6.9. PENTANE-SULFONIC ACID, 3-(N-
MORPHOLINO)PROPANESULFONIC ACID AND 1,3-DIOXO-2-
ISOINDOLINEETHANESULFONIC ACID ARE ALSO SUBSTRATES FOR THIS
ENZYME.
CATALYTIC ACTIVITY: TAURINE + 2-OXOGLUTARATE + O(2) = SULFITE +
AMINOACETALDEHYDE + SUCCINATE + CO(2).
COFACTOR: IRON AND ASCORBATE.
ENZYME REGULATION: DIVALENT METAL IONS INHIBITED.
PATHWAY: CATABOLISM OF TAURINE.
SUBUNIT: HOMODIMER.
INDUCTION: UNDER SULFUR STARVATION.
SIMILARITY: BELONGS TO THE TFDA FAMILY OF DIOXYGENASES.
CAUTION: REF.4 SEQUENCE DIFFERS FROM THAT SHOWN DUE TO
FRAMESHIFTS.
|
| 0.346145 | - | maoC | b1387 | putative aldehyde dehydrogenase |
EG13735 |
PATHWAY: AEROBIC CATABOLISM OF PHENYLACETIC ACID.
INDUCTION: ACTIVATED BY CAMP RECEPTOR PROTEIN (CRP) AND
INTEGRATION HOST FACTOR (IHF). INHIBITED BY PAAX.
SIMILARITY: BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.
|
| 0.316795 | + | ygeX | b2871 | putative dehydratase |
EG13054 |
FUNCTION: CATALYZES THE ALPHA,BETA-ELIMINATION REACTION OF BOTH L-
AND D-ALPHA,BETA-DIAMINOPROPIONATE, THE MOST SUITABLE SUBSTRATES
TO FORM PYRUVATE AND AMMONIA. THE L- AND D-ISOMERS OF SERINE ARE
ALSO DEGRADED, THOUGH SLOWLY; IT IS THE ONLY SERINE DEHYDRATASE
WHICH CAN ELIMINATE AN AMINO GROUP AT THE BETA-CARBON POSITION (BY
SIMILARITY).
CATALYTIC ACTIVITY: 2,3-DIAMINOPROPIONATE = PYRUVATE + 2 NH(3).
COFACTOR: PYRIDOXAL PHOSPHATE.
SIMILARITY: TO S.TYPHIMURIUM DIAMINOPROPIONATE AMMONIA-LYASE AND
TO THREONINE DEHYDRATASES.
|
| | ygeY | b2872 | putative deacetylase |
EG13055 |
SIMILARITY: BELONGS TO PEPTIDASE FAMILY M20A; ALSO KNOWN AS THE
ARGE/DAPE/ACY1/CPG2/YSCS FAMILY.
|
| | b2873 | b2873 | orf, hypothetical protein |
EG13056 |
SIMILARITY: BELONGS TO THE DEHYDROPYRIMIDINASE FAMILY.
|
| | yqeA | b2874 | putative kinase |
EG13057 |
SIMILARITY: BELONGS TO THE CARBAMATE KINASE FAMILY.
|
| 0.311596 | + | gloA | b1651 | lactoylglutathione lyase |
EG13421 |
FUNCTION: CATALYZES THE CONVERSION OF HEMIMERCAPTAL, FORMED
FROM METHYLGLYOXAL AND GLUTATHIONE, TO S-LACTOYLGLUTATHIONE.
CATALYTIC ACTIVITY: (R)-S-LACTOYLGLUTATHIONE = GLUTATHIONE +
METHYLGLYOXAL.
COFACTOR: BINDS ONE NICKEL ION PER MOLECULE.
PATHWAY: GLYOXAL PATHWAY.
SUBUNIT: HOMODIMER.
MASS SPECTROMETRY: MW=19419; METHOD=ELECTROSPRAY.
SIMILARITY: BELONGS TO THE GLYOXALASE I FAMILY.
|
| | rnt | b1652 | RNase T, degrades tRNA |
EG11547 |
FUNCTION: RESPONSIBLE FOR THE END-TURNOVER OF TRNA: SPECIFICALLY
REMOVES THE TERMINAL AMP RESIDUE FROM UNCHARGED TRNA (TRNA-C-C-A).
ALSO APPEARS TO BE INVOLVED IN TRNA BIOSYNTHESIS, ESPECIALLY IN
STRAINS LACKING OTHER EXORIBONUCLEASES.
SUBUNIT: HOMODIMER.
SIMILARITY: BELONGS TO THE RNASE T FAMILY.
|
| | lhr | b1653 | member of ATP-dependent helicase superfamily II |
EG11548 |
SIMILARITY: WITH OTHER ATP DEPENDENT HELICASES.
|
| 0.305442 | + | ilvL | b3766 | ilvGEDA operon leader peptide |
EG11270 |
|
| | ilvG_1 | b3767 | acetolactate synthase II, large subunit, cryptic, interrupted |
EG10498 |
CATALYTIC ACTIVITY: 2-ACETOLACTATE + CO(2) = 2-PYRUVATE (THIS
ENZYME ALSO CATALYZES FORMATION OF 2-ACETO-2-HYDROXYBUTANOATE).
COFACTOR: THIAMINE PYROPHOSPHATE, AND MAGNESIUM ION.
PATHWAY: FIRST STEP IN VALINE AND ISOLEUCINE BIOSYNTHESIS.
SUBUNIT: TETRAMER OF TWO LARGE AND TWO SMALL CHAINS.
MISCELLANEOUS: E.COLI CONTAINS GENES FOR 3 AHAS ISOZYMES: ILVBN,
ILVGM AND ILVIH. ONLY THE VAL-INHIBITABLE ILVBN & ILVIH ARE
EXPRESSED. ILVG, VAL-RESISTANT, IS EXPRESSED IN STRAINS HAVING
THE ILV0 MUTATION. THE ILV02096 MUTATION (AN INSERTION OF 2 BP)
CAUSES A FRAMESHIFT IN TRANSLATION, PERMITTING THE EXPRESSION OF
THIS ISOZYME.
SIMILARITY: WITH OTHER ENZYMES WHICH REQUIRE TPP.
|
| 0.290934 | + | yaaF | b0030 | orf, hypothetical protein |
EG11082 |
SIMILARITY: BELONGS TO THE IUNH FAMILY.
|
| 0.287811 | + | hydH | b4003 | sensor kinase for HydG, hydrogenase 3 activity |
EG10008 |
FUNCTION: MEMBER OF THE TWO-COMPONENT REGULATORY SYSTEM HYDH/HYDG
INVOLVED IN THE REGULATION OF THE LABILE HYDROGENASE ACTIVITY.
HYDH MAY FUNCTION AS A MEMBRANE-ASSOCIATED PROTEIN KINASE THAT
PHOSPHORYLATES HYDG IN RESPONSE TO ENVIRONMENTAL SIGNALS.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(PROBABLE).
SIMILARITY: TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE
KINASES.
|
| | hydG | b4004 | response regulator of hydrogenase 3 activity (sensor HydH) |
EG10482 |
FUNCTION: MEMBER OF THE TWO-COMPONENT REGULATORY SYSTEM HYDH/HYDG
INVOLVED IN THE REGULATION OF THE LABILE HYDROGENASE ACTIVITY.
WHEN ACTIVATED BY HYDH IT ACTS IN CONJUNCTION WITH SIGMA-54 AS A
TRANSCRIPTIONAL ACTIVATOR.
SUBCELLULAR LOCATION: CYTOPLASMIC (PROBABLE).
PTM: PHOSPHORYLATED BY HYDH (PROBABLE).
SIMILARITY: THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER
REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS.
SIMILARITY: THE CENTRAL REGION CONTAINS A SIGMA-54 FACTOR
INTERACTION ATP-BINDING DOMAIN.
|
| 0.268001 | + | acrD | b2470 | sensitivity to acriflavine, integral membrane protein, possible efflux pump |
EG10014 |
FUNCTION: PARTICIPATES IN THE EFFLUX OF AMINOGLYCOSIDES. CONFERS
RESISTANCE TO A VARIETY OF THESE SUBSTANCES.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(BY SIMILARITY).
SIMILARITY: BELONGS TO THE ACRB/ACRD/ACRF FAMILY.
|
| 0.258511 | - | aspC | b0928 | aspartate aminotransferase |
EG10096 |
CATALYTIC ACTIVITY: L-ASPARTATE + 2-OXOGLUTARATE = OXALOACETATE +
L-GLUTAMATE.
COFACTOR: PYRIDOXAL PHOSPHATE.
SUBUNIT: HOMODIMER.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT
AMINOTRANSFERASES.
|
| 0.255496 | + | aceE | b0114 | pyruvate dehydrogenase (decarboxylase component) |
EG10024 |
FUNCTION: THE PYRUVATE DEHYDROGENASE COMPLEX CATALYZES THE OVERALL
CONVERSION OF PYRUVATE TO ACETYL-COA & CO(2). IT CONTAINS MULTIPLE
COPIES OF THREE ENZYMATIC COMPONENTS: PYRUVATE DEHYDROGENASE (E1),
DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2) & LIPOAMIDE DEHYDROGENASE
(E3).
CATALYTIC ACTIVITY: PYRUVATE + LIPOAMIDE = S-ACETYL-DIHYDRO-
LIPOAMIDE + CO(2).
COFACTOR: THIAMINE PYROPHOSPHATE.
SUBUNIT: HOMODIMER.
|
| | aceF | b0115 | pyruvate dehydrogenase (dihydrolipoyltransacetylase component) |
EG10025 |
FUNCTION: THE PYRUVATE DEHYDROGENASE COMPLEX CATALYZES THE OVERALL
CONVERSION OF PYRUVATE TO ACETYL-COA & CO(2). IT CONTAINS MULTIPLE
COPIES OF THREE ENZYMATIC COMPONENTS: PYRUVATE DEHYDROGENASE (E1),
DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2) & LIPOAMIDE DEHYDROGENASE
(E3).
CATALYTIC ACTIVITY: ACETYL-COA + DIHYDROLIPOAMIDE = COA +
S-ACETYLDIHYDROLIPOAMIDE.
COFACTOR: THE E2 COMPONENT CONTAINS THREE COVALENTLY-BOUND LIPOYL
COFACTORS.
SUBUNIT: FORMS A 24-POLYPEPTIDE STRUCTURAL CORE WITH OCTAHEDRAL
SYMMETRY.
SIMILARITY: BELONGS TO THE 2-OXOACID DEHYDROGENASE FAMILY.
SIMILARITY: CONTAINS 3 LIPOYL-BINDING DOMAINS.
|
| 0.255136 | + | mviN | b1069 | putative virulence factor |
EG13880 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (POTENTIAL).
SIMILARITY: BELONGS TO THE MVIN FAMILY.
|
| 0.245790 | + | yjaA | b4011 | orf, hypothetical protein |
EG11206 |
|
| 0.241873 | + | yjdA | b4109 | putative vimentin |
EG11210 |
FUNCTION: BELONGS TO AN OPERON INVOLVED IN ALKYLPHOSPHONATE
UPTAKE AND C-P LYASE. EXACT FUNCTION NOT KNOWN.
MISCELLANEOUS: THE SEQUENCE SHOWN IS THAT OF STRAIN K12.
|
| | yjcZ | b4110 | orf, hypothetical protein |
EG12460 |
|
| 0.228642 | - | yagT | b0286 | putative xanthine dehydrogenase (EC 1.1.1.20) |
EG13559 |
FUNCTION: YAGR, YAGS AND YAGT COULD BE THREE SUBUNITS OF A
DEHYDROGENASE.
SIMILARITY: TO THE N-TERMINAL OF VERTEBRATE XANTHINE
DEHYDROGENASES.
SIMILARITY: TO 2FE-2S FERREDOXINS IN THE N-TERMINAL DOMAIN.
|
| | yagS | b0285 | orf, hypothetical protein |
EG13558 |
FUNCTION: YAGR, YAGS AND YAGT COULD BE THREE SUBUNITS OF A
DEHYDROGENASE.
SIMILARITY: TO R.PALUSTRIS 4-HYDROXYBENZOYL-COA REDUCTASE SUBUNIT
HBAD.
|
| | yagR | b0284 | orf, hypothetical protein |
EG13557 |
FUNCTION: YAGR, YAGS AND YAGT COULD BE THREE SUBUNITS OF A
DEHYDROGENASE.
SIMILARITY: TO VERTEBRATE XANTHINE DEHYDROGENASES AND TO
R.PALUSTRIS 4-HYDROXYBENZOYL-COA REDUCTASE SUBUNIT HBAC.
|
| | yagQ | b0283 | orf, hypothetical protein |
EG13556 |
|
| | yagP | b0282 | putative transcriptional regulator LYSR-type |
EG13555 |
SIMILARITY: SOME, TO E.COLI YAFC AND YGIP.
|
| 0.222548 | + | deoD | b4384 | purine-nucleoside phosphorylase |
EG10222 |
FUNCTION: CLEAVAGE OF GUANOSINE OR INOSINE TO RESPECTIVE BASES AND
SUGAR-1-PHOSPHATE MOLECULES.
CATALYTIC ACTIVITY: PURINE NUCLEOSIDE + ORTHOPHOSPHATE = PURINE +
ALPHA-D-RIBOSE 1-PHOSPHATE.
SUBUNIT: HOMOHEXAMER.
SIMILARITY: BELONGS TO THE PNP/UDP FAMILY 1 OF PHOSPHORYLASES.
|