Score |
Strand | Gene name |
Blattner ID |
Description |
EcoCyc link |
SwissProt comment |
| 1.422133 | + | rpsU | b3065 | 30S ribosomal subunit protein S21 |
EG10920 |
MASS SPECTROMETRY: MW=8368.8; METHOD=MALDI.
SIMILARITY: BELONGS TO THE S21P FAMILY OF RIBOSOMAL PROTEINS.
|
 | | dnaG | b3066 | DNA biosynthesis; DNA primase |
EG10239 |
FUNCTION: DNA PRIMASE IS THE POLYMERASE THAT SYNTHESIZES SMALL
RNA PRIMERS FOR THE OKAZAKI FRAGMENTS ON BOTH TEMPLATE STRANDS AT
REPLICATION FORKS DURING CHROMOSOMAL DNA SYNTHESIS.
COFACTOR: BINDS ONE ZINC ION PER MOLECULE.
SUBUNIT: MONOMER.
CAUTION: REF.2 SEQUENCE DIFFERS FROM THAT SHOWN IN POSITIONS 106
TO 169 DUE TO FRAMESHIFTS.
|
| 0.463871 | - | rpsJ | b3321 | 30S ribosomal subunit protein S10 |
EG10909 |
FUNCTION: THIS PROTEIN IS INVOLVED IN THE BINDING OF TRNA TO THE
RIBOSOMES.
MASS SPECTROMETRY: MW=11734.5; METHOD=MALDI.
SIMILARITY: BELONGS TO THE S10P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rplC | b3320 | 50S ribosomal subunit protein L3 |
EG10866 |
FUNCTION: THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL RNA AND MAY
PARTICIPATE IN THE FORMATION OF THE PEPTIDYLTRANSFERASE CENTER OF
THE RIBOSOME.
MASS SPECTROMETRY: MW=22257.2; METHOD=MALDI.
SIMILARITY: BELONGS TO THE L3P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rplD | b3319 | 50S ribosomal subunit protein L4, regulates expression of S10 operon |
EG10867 |
FUNCTION: THIS PROTEIN BINDS DIRECTLY AND SPECIFICALLY TO 23S
RRNA.
FUNCTION: PROTEIN L4 IS ALSO A TRANSLATIONAL REPRESSOR PROTEIN, IT
CONTROLS THE TRANSLATION OF THE S10 OPERON (TO WHICH BELONG L4) BY
BINDING TO ITS MRNA.
MASS SPECTROMETRY: MW=22086.2; METHOD=MALDI.
SIMILARITY: BELONGS TO THE L4P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rplW | b3318 | 50S ribosomal subunit protein L23 |
EG10883 |
FUNCTION: BINDS TO A SPECIFIC REGION ON THE 23S RRNA.
MASS SPECTROMETRY: MW=11198.0; METHOD=MALDI.
SIMILARITY: BELONGS TO THE L23P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rplB | b3317 | 50S ribosomal subunit protein L2 |
EG10865 |
FUNCTION: THIS PROTEIN IS A PRIMARY 23S RRNA-BINDING PROTEIN. IT
HAS PEPTIDYLTRANSFERASE ACTIVITY.
MASS SPECTROMETRY: MW=29732.3; METHOD=MALDI.
SIMILARITY: BELONGS TO THE L2P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rpsS | b3316 | 30S ribosomal subunit protein S19 |
EG10918 |
FUNCTION: PROTEIN S19 FORMS A COMPLEX WITH S13 THAT BINDS STRONGLY
TO THE 16S RIBOSOMAL RNA.
MASS SPECTROMETRY: MW=10299.6; METHOD=MALDI.
SIMILARITY: BELONGS TO THE S19P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rplV | b3315 | 50S ribosomal subunit protein L22 |
EG10882 |
FUNCTION: THIS PROTEIN BINDS SPECIFICALLY TO 23S RRNA; ITS BINDING
IS STIMULATED BY OTHER RIBOSOMAL PROTEINS, E.G., L4, L17, AND L20.
IT IS IMPORTANT DURING THE EARLY STAGES OF 50S RECONSTITUTION.
MASS SPECTROMETRY: MW=12225.3; METHOD=MALDI.
SIMILARITY: BELONGS TO THE L22P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rpsC | b3314 | 30S ribosomal subunit protein S3 |
EG10902 |
FUNCTION: THIS PROTEIN IS INVOLVED IN THE BINDING OF INITIATOR
MET-TRNA.
MASS SPECTROMETRY: MW=25851.9; METHOD=MALDI.
SIMILARITY: BELONGS TO THE S3P FAMILY OF RIBOSOMAL PROTEINS.
SIMILARITY: CONTAINS 1 KH DOMAIN.
|
| | rplP | b3313 | 50S ribosomal subunit protein L16 |
EG10877 |
FUNCTION: THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL RNA AND IS
LOCATED AT THE A SITE OF THE PEPTIDYLTRANSFERASE CENTER.
MASS SPECTROMETRY: MW=15326.2; METHOD=MALDI.
SIMILARITY: BELONGS TO THE L16P FAMILY OF RIBOSOMAL PROTEINS.
|
| | rpmC | b3312 | 50S ribosomal subunit protein L29 |
EG10887 |
MASS SPECTROMETRY: MW=7273.4; METHOD=MALDI.
SIMILARITY: BELONGS TO THE L29P FAMILY OF RIBOSOMAL PROTEINS.
CAUTION: REF.3 SEQUENCE DIFFERS FROM THAT SHOWN DUE TO AN EXCHANGE
OF TWO TRYPTIC PEPTIDES.
|
| | rpsQ | b3311 | 30S ribosomal subunit protein S17 |
EG10916 |
FUNCTION: PROTEIN S17 BINDS SPECIFICALLY TO THE 5' END OF 16S
RIBOSOMAL RNA. S17 IS THOUGHT TO BE INVOLVED IN THE RECOGNITION OF
TERMINATION CODONS.
MASS SPECTROMETRY: MW=9573.0; METHOD=MALDI.
SIMILARITY: BELONGS TO THE S17P FAMILY OF RIBOSOMAL PROTEINS.
|
| 0.446505 | + | mltC | b2963 | membrane-bound lytic murein transglycosylase C |
EG12986 |
FUNCTION: MUREIN-DEGRADING ENZYME. MAY PLAY A ROLE IN RECYCLING OF
MUROPEPTIDES DURING CELL ELONGATION AND/OR CELL DIVISION (BY
SIMILARITY).
CATALYTIC ACTIVITY: CLEAVAGE OF THE BETA-1,4-GLYCOSIDIC BOND
BETWEEN N-ACETYLMURAMIC ACID AND N-ACETYLGLUCOSAMINE RESIDUES,
THEREBY CONSERVING THE ENERGY IN A NEWLY SYNTHESIZED
1,6-ANHYDROBOND IN THE MURAMIC ACID RESIDUE.
SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A LIPID
ANCHOR (PROBABLE).
SIMILARITY: STRONG, TO H.INFLUENZAE MLTC.
|
| 0.445180 | + | yahM | b0327 | orf, hypothetical protein |
EG13597 |
|
| 0.388387 | - | ygjD | b3064 | putative O-sialoglycoprotein endopeptidase |
EG11171 |
FUNCTION: COULD BE A METALLOPROTEASE.
CATALYTIC ACTIVITY: HYDROLYSIS OF O-SIALOGLYCOPROTEINS; CLEAVES
31-ARG-|-ASP-32 BOND IN GLYCOPHORIN A. DOES NOT CLEAVE
UNGLYCOSYLATED PROTEINS, DESIALYLATED GLYCOPROTEINS OR
GLYCOPROTEINS THAT ARE ONLY N-GLYCOSYLATED.
COFACTOR: ZINC (PROBABLE).
SIMILARITY: BELONGS TO PEPTIDASE FAMILY M22; ALSO KNOWN AS THE
GLYCOPROTEASE FAMILY.
|
| 0.246353 | + | yigL | b3826 | orf, hypothetical protein |
EG11470 |
SIMILARITY: BELONGS TO THE COF/YBHA/YIDA/YIGL (E.COLI) / YCSE/YXEH
(B.SUBTILIS) FAMILY. STRONG, TO H.INFLUENZAE HI0597.
CAUTION: THIS IS A CONCEPTUAL TRANSLATION; REF.1 SEQUENCE DIFFERS
FROM THAT SHOWN DUE TO FRAMESHIFTS.
|
| 0.225616 | + | tolC | b3035 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes |
EG11009 |
FUNCTION: REQUIRED FOR PROPER EXPRESSION OF OUTER MEMBRANE PROTEIN
GENES SUCH AS OMPF, NMPC, PROTEIN 2, HEMOLYSIN, COLICIN V, OR
COLICIN E1. MAY BE SPECIALIZED FOR SIGNAL SEQUENCE INDEPENDENT,
EXTRACELLULAR SECRETION IN GRAM-NEGATIVE BACTERIA.
SUBCELLULAR LOCATION: OUTER MEMBRANE.
SIMILARITY: BELONGS TO THE PRTF FAMILY OF SECRETION PROTEINS.
CAUTION: REF.2 SEQUENCE WAS EXTENSIVELY CORRECTED BY REF.1.
|
| | ygiA | b3036 | orf, hypothetical protein |
|
|
| | ygiB | b3037 | orf, hypothetical protein |
EG11164 |
|
| | ygiC | b3038 | putative synthetase/amidase |
EG11165 |
SIMILARITY: STRONG, TO H.INFLUENZAE HI0929.
SIMILARITY: STRONG, TO THE N-TERMINAL OF E.COLI GSP AND TO E.COLI
YJFC.
|
| 0.215533 | + | yhdW | b3268 | putative periplasmic binding transport protein |
EG12834 |
FUNCTION: PROBABLY PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT
SYSTEM YDHWXYZ FOR AN AMINO ACID.
SUBCELLULAR LOCATION: PERIPLASMIC (PROBABLE).
SIMILARITY: BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING
PROTEIN FAMILY 3. SEEMS TO BE THE ORTHOLOG OF R.LEGUMINOSARUM
AAPJ.
CAUTION: THIS IS A CONCEPTUAL TRANSLATION; FRAMESHIFTS HAD TO BE
INTRODUCED IN POSITION 23 AND 34 TO PRODUCE THIS ORF.
|
| | yhdX | b3269 | putative transport system permease protein |
EG12835 |
FUNCTION: PROBABLY PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT
SYSTEM YDHWXYZ FOR AN AMINO ACID; PROBABLY RESPONSIBLE FOR THE
TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(POTENTIAL).
SIMILARITY: WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-
PROTEIN-DEPENDENT TRANSPORT SYSTEMS. BELONGS TO THE HISMQ
SUBFAMILY. SEEMS TO BE THE ORTHOLOG OF R.LEGUMINOSARUM AAPQ.
|
| | yhdY | b3270 | putative transport system permease protein |
EG12836 |
FUNCTION: PROBABLY PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT
SYSTEM YDHWXYZ FOR AN AMINO ACID; PROBABLY RESPONSIBLE FOR THE
TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(POTENTIAL).
SIMILARITY: WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-
PROTEIN-DEPENDENT TRANSPORT SYSTEMS. BELONGS TO THE HISMQ
SUBFAMILY. SEEMS TO BE THE ORTHOLOG OF R.LEGUMINOSARUM AAPM.
|
| | yhdZ | b3271 | putative ATP-binding component of a transport system |
EG12837 |
FUNCTION: PROBABLY PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT
SYSTEM YDHWXYZ FOR AN AMINO ACID. PROBABLY RESPONSIBLE FOR ENERGY
COUPLING TO THE TRANSPORT SYSTEM.
SUBCELLULAR LOCATION: INNER MEMBRANE-ASSOCIATED (POTENTIAL).
SIMILARITY: BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY
(ABC TRANSPORTERS). SEEMS TO BE THE ORTHOLOG OF R.LEGUMINOSARUM
AAPP.
|
| 0.202352 | + | b1450 | b1450 | orf, hypothetical protein |
EG13773 |
SIMILARITY: BELONGS TO THE GNTR FAMILY OF TRANSCRIPTIONAL
REGULATORS.
|
| 0.177659 | + | yeaV | b1801 | putative transport protein |
EG13508 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(PROBABLE).
SIMILARITY: BELONGS TO THE BCCT (TC 2.33) FAMILY OF TRANSPORTERS.
|
| | yeaW | b1802 | orf, hypothetical protein |
EG13509 |
COFACTOR: PROBABLY BINDS A 2FE-2S GROUP AND AN IRON ATOM.
SUBUNIT: PROBABLE HETERODIMER OF YEAW AND YEAX.
SIMILARITY: BELONGS TO THE BACTERIAL RING-HYDROXYLATING
DIOXYGENASE ALPHA SUBUNIT FAMILY.
|
| | yeaX | b1803 | putative diogenase beta subunit |
EG13510 |
COFACTOR: FMN (BY SIMILARITY).
SUBUNIT: PROBABLE HETERODIMER OF YEAW AND YEAX.
SIMILARITY: IN THE C-TERMINAL, BELONGS TO THE 2FE2S PLANT-TYPE
FERREDOXIN FAMILY.
SIMILARITY: BELONGS TO THE PDR/VANB FAMILY.
|
| 0.157430 | + | ygfO | b2882 | putative transport protein |
EG13065 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (PROBABLE).
SIMILARITY: BELONGS TO THE XANTHINE/URACIL PERMEASES FAMILY.
|
| | ygfP | b2883 | orf, hypothetical protein |
EG13066 |
FUNCTION: CATALYZES THE HYDROLYTIC DEAMINATION OF GUANINE,
PRODUCING XANTHINE AND AMMONIA.
CATALYTIC ACTIVITY: GUANINE + H(2)O = XANTHINE + NH(3).
COFACTOR: CONTAINS 1 MOLE OF ZINC PER SUBUNIT.
PATHWAY: PURINE NUCLEOTIDE CATABOLISM.
SIMILARITY: BELONGS TO THE ATZ/TRZ FAMILY.
|
| | ygfQ | b2884 | orf, hypothetical protein |
EG13067 |
SIMILARITY: BELONGS TO THE YICO/YIEG/YJCD FAMILY. CORRESPONDS TO
THE N-TERMINAL PART; THE C-TERMINAL PART IS YGFR.
|
| | ygfR | b2885 | putative oxidoreductase |
EG13068 |
SIMILARITY: BELONGS TO THE YICO/YIEG/YJCD FAMILY. CORRESPONDS TO
THE C-TERMINAL PART; THE N-TERMINAL PART IS YGFQ.
|
| 0.148649 | + | ydcH | b1426 | orf, hypothetical protein |
EG12865 |
|
| | rimL | b1427 | acetylation of N-terminal serine of 30S ribosomal subunit protein L7; acetyl transferase |
EG10853 |
FUNCTION: THIS ENZYME ACETYLATES THE N-TERMINAL SERINE OF
RIBOSOMAL PROTEIN L7/L12.
CATALYTIC ACTIVITY: ACETYL-COA + RIBOSOMAL-PROTEIN L-SERINE =
COA + RIBOSOMAL-PROTEIN N-ACETYL-L-SERINE.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO THE ACETYLTRANSFERASE FAMILY. RIML
SUBFAMILY.
|
| 0.140399 | + | trs5_4 | b1331 | IS5 transposase |
|
|
| 0.137576 | + | ilvD | b3771 | dihydroxyacid dehydratase |
EG10496 |
CATALYTIC ACTIVITY: 2,3-DIHYDROXY-3-METHYLBUTANOATE = 3-METHYL-2-
OXOBUTANOATE + H(2)O.
COFACTOR: BINDS A 4FE-4S CLUSTER.
PATHWAY: FOURTH STEP IN VALINE AND ISOLEUCINE BIOSYNTHESIS.
SIMILARITY: BELONGS TO THE ILVD / EDD FAMILY.
|
| | ilvA | b3772 | threonine deaminase (dehydratase) |
EG10493 |
FUNCTION: DEAMINATES L-THREONINE, BUT ALSO L-SERINE TO A LESSER
EXTENT.
CATALYTIC ACTIVITY: L-THREONINE + H(2)O = 2-OXOBUTANOATE + NH(3)
+ H(2)O.
COFACTOR: PYRIDOXAL PHOSPHATE.
ENZYME REGULATION: ISOLEUCINE ALLOSTERICALLY INHIBITS WHILE
VALINE ALLOSTERICALLY ACTIVATES THIS ENZYME.
PATHWAY: FIRST STEP OF ISOLEUCINE BIOSYNTHESIS.
SUBUNIT: HOMOTETRAMER.
SIMILARITY: TO THREONINE DEHYDRATASE CATABOLIC AND SERINE
DEHYDRATASE.
|
| 0.134116 | + | gcvR | b2479 | transcriptional regulation of gcv operon |
EG11149 |
FUNCTION: NEGATIVE TRANSCRIPTIONAL REGULATOR OF THE GLYCINE
CLEAVAGE SYSTEM OPERON (GCV). DOES NOT AUTOREGULATE ITS OWN
EXPRESSION. IT IS NOT YET KNOWN HOW GCVR ACTS AS A REPRESSOR. IT
DOES NOT SEEM TO BIND DNA. IT COULD INTERACT WITH GCVA AND
SUPPRESS ITS ACTIVATORY ACTIVITY.
SUBCELLULAR LOCATION: CYTOPLASMIC.
|
| | bcp | b2480 | bacterioferritin comigratory protein |
EG10108 |
SIMILARITY: BELONGS TO THE AHPC/TSA FAMILY.
|
| 0.132956 | + | ybbY | b0513 | putative transport |
EG13620 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (POTENTIAL).
INDUCTION: BY GLYOXYLATE.
SIMILARITY: BELONGS TO THE XANTHINE/URACIL PERMEASES FAMILY.
STRONG, TO B.SUBTILIS YWDJ.
|
| | ybbZ | b0514 | orf, hypothetical protein |
EG13621 |
CATALYTIC ACTIVITY: ATP + (R)-GLYCERATE = ADP + 3-PHOSPHO-(R)-
GLYCERATE.
PATHWAY: GLYOXYLATE CATABOLISM.
INDUCTION: BY GLYOXYLATE.
SIMILARITY: BELONGS TO THE UPF0068 FAMILY.
|
| 0.113890 | - | phnQ | b4091 | orf, hypothetical protein |
|
MISCELLANEOUS: THE SEQUENCE SHOWN IS THAT OF STRAIN K12.
CAUTION: THIS SEQUENCE, ACCORDING TO THE ECOSEQ DATABASE (K. RUDD)
AS WELL AS WANNER B.L. IS MOST PROBABLY NOT A REAL PROTEIN;
THEREFORE THIS ENTRY WILL PROBABLY BE DELETED IN FUTURE RELEASES.
|
| 0.110680 | + | mdoG | b1048 | periplasmic glucans biosynthesis protein |
EG11885 |
FUNCTION: INVOLVED IN THE BIOSYNTHESIS OF PERIPLASMIC MEMBRANE-
DERIVED OLIGOSACCHARIDES (MDO).
PATHWAY: OPG (OSMOREGULATED PERIPLASMIC GLUCANS) BIOSYNTHESIS.
SUBCELLULAR LOCATION: PERIPLASMIC.
SIMILARITY: TO P.SYRINGAE HYPOTHETICAL 40 KDA PROTEIN IN HRP LOCUS
(AC P20400) AND TO E.COLI YDCG.
|
| | mdoH | b1049 | membrane glycosyltransferase; synthesis of membrane-derived oligosaccharide (MDO) |
EG11886 |
FUNCTION: NECESSARY FOR NORMAL GLUCOSYLTRANSFERASE ACTIVITY. IT
COULD BE A GLUCOSYL TRANSFERASE OR SIMPLY A SUBUNIT OF THIS
ENZYME.
PATHWAY: OPG (OSMOREGULATED PERIPLASMIC GLUCANS) BIOSYNTHESIS.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE.
SIMILARITY: BELONGS TO THE GLYCOSYLTRANSFERASE FAMILY 2. STRONG,
TO P.SYRINGAE HRPM.
|
| 0.109542 | + | b1757 | b1757 | putative thiosulfate sulfur transferase |
EG14007 |
CATALYTIC ACTIVITY: THIOSULFATE + CYANIDE = SULFITE + THIOCYANATE.
SIMILARITY: BELONGS TO THE RHODANESE FAMILY.
|
| 0.108225 | + | cysQ | b4214 | affects pool of 3'-phosphoadenosine-5'-phosphosulfate in pathway of sulfite synthesis |
EG10043 |
FUNCTION: COULD HELP CONTROL THE POOL OF 3'-PHOSPHOADENOSIDE
5'-PHOSPHOSULFATE, OR ITS USE IN SULFITE SYNTHESIS.
SUBCELLULAR LOCATION: PROBABLE PERIPHERAL MEMBRANE PROTEIN
LOCALIZED ON THE INNER FACE OF THE CYTOPLASMIC MEMBRANE.
INDUCTION: STRONGLY REPRESSED DURING NITROGEN EXCESS.
SIMILARITY: BELONGS TO THE INOSITOL MONOPHOSPHATASE FAMILY.
CAUTION: WAS ORIGINALLY (REF.1) THOUGHT TO BE AN AMMONIUM
TRANSPORT PROTEIN.
|
| 0.107631 | + | pheL | b2598 | leader peptide of chorismate mutase-P-prephenate dehydratase |
EG11271 |
FUNCTION: THIS PROTEIN IS INVOLVED IN CONTROL OF THE BIOSYNTHESIS
OF PHENYLALANINE.
|
| | pheA | b2599 | chorismate mutase-P and prephenate dehydratase |
EG10707 |
CATALYTIC ACTIVITY: CHORISMATE = PREPHENATE.
CATALYTIC ACTIVITY: PREPHENATE = PHENYLPYRUVATE + H(2)O + CO(2).
PATHWAY: L-PHENYLALANINE BIOSYNTHESIS.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: TO OTHER PDT ENZYMES OR DOMAINS.
|
| 0.103603 | + | yibQ | b3614 | orf, hypothetical protein |
EG12298 |
SIMILARITY: STRONG, TO H.INFLUENZAE HI0755.
|
| 0.100689 | + | hflK | b4174 | protease specific for phage lambda cII repressor |
EG10436 |
FUNCTION: HFLC AND HFLK GOVERN THE STABILITY OF PHAGE LAMBDA CII
PROTEIN AND HAVE BEEN PROPOSED TO ENCODE OR REGULATE A CII-
SPECIFIC PROTEASE.
SUBUNIT: HFLC AND HFLK MAY INTERACT TO FORM A MULTIMERIC COMPLEX.
SIMILARITY: BELONGS TO THE BAND 7 / MEC-2 FAMILY. HFLK FAMILY.
|
| | hflC | b4175 | protease specific for phage lambda cII repressor |
EG10435 |
FUNCTION: HFLC AND HFLK GOVERN THE STABILITY OF PHAGE LAMBDA CII
PROTEIN AND HAVE BEEN PROPOSED TO ENCODE OR REGULATE A CII-
SPECIFIC PROTEASE.
SUBUNIT: HFLC AND HFLK MAY INTERACT TO FORM A MULTIMERIC COMPLEX.
SIMILARITY: BELONGS TO THE BAND 7 / MEC-2 FAMILY. HFLC FAMILY.
|
| | yjeT | b4176 | orf, hypothetical protein |
EG12482 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (POTENTIAL).
|
| | purA | b4177 | adenylosuccinate synthetase |
EG10790 |
FUNCTION: PLAYS AN IMPORTANT ROLE IN THE DE NOVO PATHWAY OF PURINE
NUCLEOTIDE BIOSYNTHESIS.
CATALYTIC ACTIVITY: GTP + IMP + L-ASPARTATE = GDP + ORTHOPHOSPHATE
+ ADENYLOSUCCINATE.
PATHWAY: FIRST COMMITTED STEP IN AMP BIOSYNTHESIS.
SUBUNIT: HOMODIMER.
SIMILARITY: BELONGS TO THE ADENYLOSUCCINATE SYNTHETASE FAMILY.
|
| 0.096979 | + | ycjG | b1325 | putative muconate cycloisomerase I (EC 5.5.-.-) |
EG13228 |
SIMILARITY: BELONGS TO THE MANDELATE RACEMASE / MUCONATE
LACTONIZING ENZYME FAMILY.
CAUTION: REF.1 SEQUENCE DIFFERS FROM THAT SHOWN DUE TO A STOP
CODON IN POSITION 275 AND A FRAMESHIFT IN POSITION 285.
|
| 0.096096 | + | yiiM | b3910 | orf, hypothetical protein |
EG11870 |
SIMILARITY: TO H.INFLUENZAE HI0278.
|
| 0.095375 | + | ybaN | b0468 | putative gene 58 |
EG12843 |
|
| 0.095280 | + | sbp | b3917 | periplasmic sulfate-binding protein |
EG10929 |
FUNCTION: THIS PROTEIN SPECIFICALLY BINDS SULFATE AND IS INVOLVED
IN ITS TRANSMEMBRANE TRANSPORT.
SUBCELLULAR LOCATION: PERIPLASMIC.
SIMILARITY: BELONGS TO THE PROKARYOTIC SULFATE BINDING PROTEIN
FAMILY.
|
| | cdh | b3918 | CDP-diacylglycerol phosphotidylhydrolase |
EG10138 |
CATALYTIC ACTIVITY: CDP-DIACYLGLYCEROL + H(2)O = CMP +
PHOSPHATIDATE.
PATHWAY: PHOSPHOLIPID BIOSYNTHESIS.
SUBCELLULAR LOCATION: INNER MEMBRANE-ASSOCIATED.
SIMILARITY: BELONGS TO THE CDH FAMILY.
CAUTION: REF.2 SEQUENCE WAS INCORRECT IN THE CENTRAL PART DUE
TO A FRAMESHIFT.
|
| 0.094149 | + | b4286 | b4286 | orf, hypothetical protein |
|
CAUTION: THIS SEQUENCE, ACCORDING TO THE ECOSEQ DATABASE (K. RUDD)
IS PROBABLY NOT A REAL PROTEIN; THEREFORE THIS ENTRY WILL PROBABLY
BE DELETED IN FUTURE RELEASES.
|
| 0.093872 | + | b2845 | b2845 | putative transporter protein |
EG13098 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(POTENTIAL).
SIMILARITY: BELONGS TO THE SDAC/TDCC FAMILY OF TRANSPORTERS.
|
| 0.093744 | + | b0968 | b0968 | orf, hypothetical protein |
EG13726 |
CATALYTIC ACTIVITY: AN ACYLPHOSPHATE + H(2)O = A FATTY ACID ANION
+ ORTHOPHOSPHATE.
SIMILARITY: BELONGS TO THE ACYLPHOSPHATASE FAMILY.
|
| 0.092646 | - | argT | b2310 | lysine-, arginine-, ornithine-binding periplasmic protein |
EG10072 |
FUNCTION: THIS PERIPLASMIC BINDING PROTEIN IS INVOLVED IN AN
ARGININE TRANSPORT SYSTEM. ARGT AND HISTIDINE-BINDING PROTEIN J
(HISJ) INTERACT WITH A COMMON MEMBRANE-BOUND RECEPTOR, HISP.
SUBCELLULAR LOCATION: PERIPLASMIC.
PTM: PHOSHORYLATED BY ARGK.
SIMILARITY: BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING
PROTEIN FAMILY 3.
|
| 0.089482 | - | rnc | b2567 | RNase III, ds RNA |
EG10857 |
FUNCTION: DIGESTS DOUBLE-STRANDED RNA. INVOLVED IN THE PROCESSING
OF RIBOSOMAL RNA PRECURSORS AND OF SOME MRNAS.
CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE TO 5'-PHOSPHO-
MONOESTER.
SUBUNIT: ORGANIZED INTO A STRUCTURE (PROCESSOME) CONTAINING A
NUMBER OF RNA-PROCESSING ENZYMES.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: CONTAINS 1 DRBM (DOUBLE-STRANDED RNA-BINDING) DOMAIN.
SIMILARITY: BELONGS TO THE RNASE III FAMILY.
|
| | era | b2566 | GTP-binding protein |
EG10270 |
FUNCTION: BINDS BOTH GDP AND GTP, HAS AN INTRINSIC GTPASE ACTIVITY
AND IS ESSENTIAL FOR CELL GROWTH.
SUBCELLULAR LOCATION: MEMBRANE-BOUND.
PTM: AUTOPHOSPHORYLATED.
SIMILARITY: BELONGS TO THE ERA/TRME FAMILY OF GTP-BINDING
PROTEINS. ERA SUBFAMILY.
SIMILARITY: CONTAINS 1 KH DOMAIN.
|
| | recO | b2565 | protein interacts with RecR and possibly RecF proteins |
EG10832 |
FUNCTION: INVOLVED IN DNA REPAIR AND RECF PATHWAY RECOMBINATION.
SIMILARITY: BELONGS TO THE RECO FAMILY.
|
| | pdxJ | b2564 | pyridoxine biosynthesis |
EG10693 |
FUNCTION: CATALYZES THE CONDENSATION OF 1-DEOXY-D-XYLULOSE-5-
PHOSPHATE (DXP) AND 1-AMINO-3-OXO-4-(PHOSPHOHYDROXY)PROPAN-2-ONE
TO FORM PYRIDOXINE 5'-PHOSPHATE (PNP).
PATHWAY: DE NOVO SYNTHESIS OF PYRIDOXINE (VITAMIN B6) AND
PYRIDOXAL PHOSPHATE.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO THE PDXJ FAMILY.
CAUTION: REF.3 SEQUENCE DIFFERS FROM THAT SHOWN DUE TO NUMEROUS
FRAMESHIFTS.
|
| | acpS | b2563 | CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase |
EG10247 |
FUNCTION: TRANSFERS THE 4'-PHOSPHOPANTETHEINE MOIETY FROM COENZYME
A TO THE SER-36 OF ACYL-CARRIER PROTEIN.
CATALYTIC ACTIVITY: COA + APO-[ACYL-CARRIER PROTEIN] = ADENOSINE
3',5'-BISPHOSPHATE + HOLO-[ACYL-CARRIER PROTEIN].
COFACTOR: REQUIRES MAGNESIUM.
SUBUNIT: HOMODIMER.
SUBCELLULAR LOCATION: CYTOPLASMIC (PROBABLE).
MASS SPECTROMETRY: MW=13950; METHOD=ELECTROSPRAY.
SIMILARITY: BELONGS TO THE ACPS FAMILY.
|
| 0.086404 | + | b2659 | b2659 | orf, hypothetical protein |
EG13523 |
FUNCTION: MAY BE INVOLVED IN THE CONTROL OF UTILIZATION OF GAMA-
AMINOBUTYRIC ACID.
|
| | ygaF | b2660 | orf, hypothetical protein |
EG12387 |
|
| | gabD | b2661 | succinate-semialdehyde dehydrogenase, NADP-dependent activity |
EG11329 |
CATALYTIC ACTIVITY: SUCCINATE SEMIALDEHYDE + NAD(P)(+) + H(2)O
= SUCCINATE + NAD(P)H.
PATHWAY: 4-AMINOBUTYRATE (GABA) DEGRADATION PATHWAY.
SIMILARITY: BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.
|
| | gabT | b2662 | 4-aminobutyrate aminotransferase activity |
EG10361 |
CATALYTIC ACTIVITY: 4-AMINOBUTANOATE + 2-OXOGLUTARATE = SUCCINATE
SEMIALDEHYDE + L-GLUTAMATE.
COFACTOR: PYRIDOXAL PHOSPHATE.
PATHWAY: 4-AMINOBUTYRATE (GABA) DEGRADATION PATHWAY.
SUBUNIT: HOMODIMER.
INDUCTION: CATABOLITE REPRESSION BY GLUCOSE (REPRESSION RELIEVED
BY GABA).
SIMILARITY: BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT
AMINOTRANSFERASES.
|
| 0.086285 | + | yaeS | b0174 | orf, hypothetical protein |
EG13329 |
FUNCTION: GENERATES UNDECAPRENYL PYROPHOSPHATE (UPP) FROM
ISOPENTENYL PYROPHOSPHATE (IPP). UPP IS THE PRECURSOR OF THE
CARRIER LIPID FOR PEPTIDOGLYCAN SYNTHESIS.
CATALYTIC ACTIVITY: DI-TRANS-POLY-CIS-DECAPRENYL DIPHOSPHATE +
ISOPENTENYL DIPHOSPHATE = DIPHOSPHATE + DI-TRANS-POLY-CIS-
UNDECAPRENYL DIPHOSPHATE.
SIMILARITY: BELONGS TO THE UPP SYNTHETASE FAMILY.
|
| | cdsA | b0175 | CDP-diglyceride synthetase |
EG10139 |
CATALYTIC ACTIVITY: CTP + PHOSPHATIDATE = PYROPHOSPHATE +
CDP-DIACYLGLYCEROL.
PATHWAY: PHOSPHOLIPID BIOSYNTHESIS.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE.
SIMILARITY: BELONGS TO THE CDS FAMILY.
|
| | yaeL | b0176 | orf, hypothetical protein |
EG12436 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (POTENTIAL).
SIMILARITY: BELONGS TO THE YAEL/HI0918/HP0258/SLR1821 FAMILY.
SIMILARITY: CONTAINS 1 PDZ/DHR DOMAIN.
|
| | yaeT | b0177 | orf, hypothetical protein |
EG12676 |
SUBCELLULAR LOCATION: OUTER MEMBRANE (POTENTIAL).
SIMILARITY: BELONGS TO THE SURFACE ANTIGEN D15 FAMILY.
|
| | hlpA | b0178 | histone-like protein, located in outer membrane or nucleoid |
EG10455 |
SUBUNIT: HOMOTETRAMER.
SUBCELLULAR LOCATION: EITHER IN THE NUCLEOID (CHROMATIN) OR IN
THE OUTER MEMBRANE.
SIMILARITY: TO OTHER SPECIES OMPH OUTER MEMBRANE PROTEIN.
|
| | lpxD | b0179 | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; third step of endotoxin (lipidA) synthesis |
EG10316 |
CATALYTIC ACTIVITY: UDP-3-O-(3-HYDROXYTETRADECANOYL)GLUCOSAMINE
+ (R)-3-HYDROXYTETRADECANOYL-[ACYL-CARRIER PROTEIN] =
UDP-2,3-BIS(3-HYDROXYTETRADECANOYL)GLUCOSAMINE + [ACYL-CARRIER
PROTEIN].
PATHWAY: THIRD STEP IN LIPID A BIOSYNTHESIS.
MISCELLANEOUS: THE MUTANTS FIRA200, FIRA201 AND OMSA CONFER
TEMPERATURE SENSITIVITY. FIRA200 REVERSES THE RIFAMPIN RESISTANCE
OF RPOB MUTANTS.
SIMILARITY: BELONGS TO THE CYSE/LACA/LPXA/NODL FAMILY OF
ACETYLTRANSFERASES. COMPOSED OF MULTIPLE REPEATS OF [LIV]-G-X(4).
CAUTION: WAS ORIGINALLY THOUGHT TO BE INVOLVED IN TRANSCRIPTION.
|
| | fabZ | b0180 | (3R)-hydroxymyristol acyl carrier protein dehydratase |
EG11284 |
FUNCTION: INVOLVED IN SATURATED FATTY ACIDS BIOSYNTHESIS.
SUBUNIT: OLIGOMER.
SUBCELLULAR LOCATION: CYTOPLASMIC.
PTM: THE N-TERMINUS IS BLOCKED.
SIMILARITY: BELONGS TO THE THIOESTER DEHYDRATASE FAMILY.
|
| | lpxA | b0181 | UDP-N-acetylglucosamine acetyltransferase; lipid A biosynthesis |
EG10545 |
FUNCTION: INVOLVED IN THE BIOSYNTHESIS OF LIPID A, A
PHOSPHORYLATED GLYCOLIPID THAT ANCHORS THE LIPOPOLYSACCHARIDE TO
THE OUTER MEMBRANE OF THE CELL.
CATALYTIC ACTIVITY: (R)-3-HYDROXYTETRADECANOYL-[ACYL-CARRIER
PROTEIN] + UDP-N-ACETYLGLUCOSAMINE = [ACYL-CARRIER PROTEIN] +
UDP-3-O-(3-HYDROXYTETRADECANOYL)-N-ACETYLGLUCOSAMINE.
PATHWAY: LIPID A BIOSYNTHESIS; FIRST STEP.
SUBUNIT: HOMOTRIMER.
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO THE TRANSFERASE HEXAPEPTIDE REPEAT FAMILY.
LPXA SUBFAMILY.
|
| | lpxB | b0182 | tetraacyldisaccharide-1-P; lipid A biosynthesis, penultimate step |
EG10546 |
FUNCTION: CONDENSATION OF UDP-2,3-DIACYLGLUCOSAMINE AND
2,3-DIACYLGLUCOSAMINE-1-PHOSPHATE TO FORM LIPID A DISACCHARIDE,
A PRECURSOR OF LIPID A, A PHOSPHORYLATED GLYCOLIPID THAT ANCHORS
THE LIPOPOLYSACCHARIDE TO THE OUTER MEMBRANE OF THE CELL.
CATALYTIC ACTIVITY: UDP-2,3-BIS(3-HYDROXYTETRADECANOYL)GLUCOSAMINE
+ 2,3-BIS(3-HYDROXYTETRADECANOYL)-BETA-D-GLUCOSAMINYL 1-PHOSPHATE
= UDP + 2,3-BIS(3-HYDROXYTETRADECANOYL)-D-GLUCOSAMINYL-1,6-BETA-
D-2,3-BIS(3-HYDROXYTETRADECANOYL)-BETA-D-GLUCOSAMINYL 1-PHOSPHATE.
PATHWAY: LIPID A BIOSYNTHESIS.
SIMILARITY: BELONGS TO THE LPXB FAMILY.
|
| | rnhB | b0183 | RNAse HII, degrades RNA of DNA-RNA hybrids |
EG10861 |
FUNCTION: DEGRADES THE RIBONUCLEOTIDE MOIETY ON RNA-DNA HYBRID
MOLECULES.
CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE TO 5'-PHOSPHO-
MONOESTER.
COFACTOR: REQUIRES MANGANESE FOR ACTIVITY.
SUBCELLULAR LOCATION: CYTOPLASMIC (POTENTIAL).
SIMILARITY: BELONGS TO THE RNASE HII FAMILY.
|
| | dnaE | b0184 | DNA polymerase III, alpha subunit |
EG10238 |
FUNCTION: DNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME
RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA.
THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' EXONUCLEASE ACTIVITY.
THE ALPHA CHAIN IS THE DNA POLYMERASE.
CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE =
N PYROPHOSPHATE + DNA(N).
SUBUNIT: CONTAINS A CORE (COMPOSED OF ALPHA, EPSILON, AND THETA
CHAINS) THAT ASSOCIATES WITH A TAU SUBUNIT WHICH ALLOW THE CORE
DIMERIZATION TO FORM THE POLIII' COMPLEX. POLIII' ASSOCIATES WITH
THE GAMMA COMPLEX (COMPOSED OF CHAINS GAMMA, DELTA, DELTA', PSI,
AND CHI) AND WITH THE BETA CHAIN. THE FINAL COMPOSITION OF THE
COMPLEX IS: (ALPHA,EPSILON,THETA)[2]-TAU[2]-(GAMMA,DELTA,DELTA',
PSI,CHI)[2]-BETA[4].
SUBCELLULAR LOCATION: CYTOPLASMIC.
SIMILARITY: BELONGS TO DNA POLYMERASE TYPE-C FAMILY. DNAE
SUBFAMILY.
|
| | accA | b0185 | acetylCoA carboxylase, carboxytransferase component, alpha subunit |
EG11647 |
FUNCTION: THIS PROTEIN IS A COMPONENT OF THE ACETYL COENZYME A
CARBOXYLASE COMPLEX; FIRST, BIOTIN CARBOXYLASE CATALYZES THE
CARBOXYLATION OF THE CARRIER PROTEIN AND THEN THE TRANSCARBOXYLASE
TRANSFERS THE CARBOXYL GROUP TO FORM MALONYL-COA.
CATALYTIC ACTIVITY: CARBOXYBIOTIN CARBOXYL CARRIER PROTEIN +
ACETYL-COA = BIOTIN CARBOXYL CARRIER PROTEIN + MALONYL-COA.
PATHWAY: FIRST STEP IN LONG-CHAIN FATTY ACID SYNTHESIS.
SUBUNIT: ACETYL-COA CARBOXYLASE IS AN HETEROHEXAMER OF BIOTIN
CARBOXYL CARRIER PROTEIN, BIOTIN CARBOXYLASE AND THE TWO SUBUNITS
OF CARBOXYL TRANSFERASE IN A 2:2 COMPLEX.
SIMILARITY: TO THE C-TERMINUS OF MAMMALIAN PROPIONYL-COA
CARBOXYLASE BETA CHAIN.
|
| | ldcC | b0186 | lysine decarboxylase 2, constitutive |
EG13219 |
FUNCTION: LDC IS CONSTITUTIVELY BUT WEAKLY EXPRESSED UNDER VARIOUS
CONDITIONS. OPTIMUM ACTIVITY IS ACHIEVED BETWEEN PH 6.2 TO 8.0.
CATALYTIC ACTIVITY: L-LYSINE = CADAVERINE + CO(2).
COFACTOR: PYRIDOXAL PHOSPHATE.
SUBUNIT: HOMODECAMER.
SIMILARITY: BELONGS TO FAMILY 1 OF ORNITHINE, LYSINE, AND ARGININE
DECARBOXYLASES.
|
| | yaeR | b0187 | orf, hypothetical protein |
EG13224 |
SIMILARITY: STRONG, TO B.SUBTILIS YWKD.
|
| | mesJ | b0188 | cell cycle protein |
EG13220 |
SIMILARITY: BELONGS TO THE UPF0072 (MESJ/YCF62) FAMILY.
|
| 0.084939 | + | tnaA | b3708 | tryptophanase |
EG11005 |
CATALYTIC ACTIVITY: L-TRYPTOPHAN + H(2)O = INDOLE + PYRUVATE +
NH(3) (ALSO CATALYZES THE SYNTHESIS OF TRYPTOPHAN FROM INDOLE
AND SERINE).
COFACTOR: PYRIDOXAL PHOSPHATE.
SUBUNIT: HOMOTETRAMER.
SIMILARITY: HIGH, TO TYROSINE PHENOL-LYASE.
|
| | tnaB | b3709 | low affinity tryptophan permease |
EG11006 |
FUNCTION: INVOLVED IN THE TRYPTOPHAN TRANSPORT ACROSS THE
CYTOPLASMIC MEMBRANE. PLAY A ROLE IN TRANSPORTING TRYPTOPHAN
WHICH IS TO BE USED CATABOLICALLY.
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE.
INDUCTION: BY TRYPTOPHAN. IS SUBJECT TO CATABOLIC REPRESSION.
SIMILARITY: BELONGS TO THE MTR / TNAB / TYRO PERMEASE FAMILY.
|
| | yidY | b3710 | putative transport protein |
EG11720 |
SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE
(PROBABLE).
SIMILARITY: BELONGS TO THE MAJOR FACILITATOR FAMILY (ALSO KNOWN
AS THE DRUG RESISTANCE TRANSLOCASE FAMILY).
|
| | yidZ | b3711 | putative transcriptional regulator LYSR-type |
EG11721 |
SIMILARITY: BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL
REGULATORS.
|
| | yieE | b3712 | orf, hypothetical protein |
EG11722 |
|
| | yieF | b3713 | orf, hypothetical protein |
EG11723 |
SIMILARITY: BELONGS TO THE SSUE FAMILY.
|