Gene name

Blattner ID

Description

EcoCyc link

SwissProt comment

lexAb4043regulator for SOS(lexA) regulon EG10533 FUNCTION: REPRESSES A NUMBER OF GENES INVOLVED IN THE RESPONSE TO DNA DAMAGE (SOS RESPONSE), INCLUDING RECA AND LEXA. HAS BEEN SHOWN TO BIND TO THE 16 BP PALINDROMIC SEQUENCE 5'-CTGT-AT(4)-ACAG-3'. IN THE PRESENCE OF SINGLE-STRANDED DNA, RECA INTERACTS WITH LEXA CAUSING AN AUTOCATALYTIC CLEAVAGE WHICH DISRUPTS THE DNA-BINDING PART OF LEXA, LEADING TO DEREPRESSION OF THE SOS REGULON AND EVENTUALLY DNA REPAIR. CATALYTIC ACTIVITY: HYDROLYSIS OF 84-ALA-|-GLY-85 BOND IN REPRESSOR LEXA. SUBUNIT: HOMODIMER. SIMILARITY: BELONGS TO PEPTIDASE FAMILY S24; ALSO KNOWN AS THE UMUD/LEXA FAMILY.
dinFb4044DNA-damage-inducible protein F EG11491 SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (POTENTIAL). INDUCTION: BY DNA DAMAGE.
yjbJb4045orf, hypothetical protein EG11928 SIMILARITY: SOME, TO B.SUBTILIS CSBD.